C- to B-state transition of tropomyosin moving toward TnI residue 170. This video highlights the region containing tropomyosin residue E139 moving toward R170 on TnI and shows MD simulation of C-state tropomyosin pivoting to the B-state position. Cross-sectional views were taken from the 44-ns simulation highlighting the C-state tropomyosin (yellow) beginning on actin as localized in the PDB 7UTI model and then transitioning to the B-state position in the presence of C-terminal domain of TnI (blue); a static model of B-state tropomyosin (magenta) is superposed for reference. Note the salt bridge contacts formed during MD and the tropomyosin pivoting. The respective glutamate and arginine side-chain atoms are shown as red and blue spheres. The color representation matches that in Fig. 2.
