Video 1.

The abnormal gait of 9-mo-old Arl6ip1−/− mice. In 9-mo-old Arl6ip1−/− mice, exhibiting HSP disease phenotypes such as hindlimb muscle weakness and spasticity, abnormalities in mouse locomotor activity and gait were observed. Video is presented in real-time.


ARL6IP1 gene delivery reduces neuroinflammation and neurodegenerative pathology in hereditary spastic paraplegia model

Jung Hwa Lim, Hyun Mi Kang, Dae Hun Kim, Bohyeon Jeong, Da Yong Lee, Jae-Ran Lee, Jeong Yeob Baek, Hyun-Soo Cho, Mi-Young Son, Dae Soo Kim, Nam-Soon Kim, and Cho-Rok Jung

DOI: 10.1084/jem.20230367
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