Video 1.

Human NLRP1 is activated by the ribotoxic stress response. N/TERT-1C1C-EGFP cells in the presence of PI were treated with DMSO and recorded by wide-field microscopy over time. C1C-EGFP is displayed in green, PI signal in red, and phase contrast in grayscale. The time after stimulation is shown as hh:mm; the frame rate is 7 fps.


P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection

Lea-Marie Jenster, Karl-Elmar Lange, Sabine Normann, Anja von Hemdt, Jennifer D. Wuerth, Lisa D.J. Schiffelers, Yonas M. Tesfamariam, Florian N. Gohr, Laura Klein, Ines H. Kaltheuner, Stefan Ebner, Dorothee J. Lapp, Jacob Mayer, Jonas Moecking, Hidde L. Ploegh, Eicke Latz, Felix Meissner, Matthias Geyer, Beate M. Kümmerer, and Florian I. Schmidt

DOI: 10.1084/jem.20220837
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