Video 1.

LCMV infections result in acute and transient depletion of the BM erythroid cellular compartment. 3D confocal microscopy of thick femoral slices from uninfected control mice (ctrl) and mice 7 dpi with LCMV-cl13. Immunostaining against erythroid progenitors (Ter119, white) and BM sinusoidal vessels (CD105, blue). Tissue thickness was 65 µm in whole diaphysis images and 44 µm for zoomed-in images, respectively.


Chronic viral infections persistently alter marrow stroma and impair hematopoietic stem cell fitness

Stephan Isringhausen, YeVin Mun, Larisa Kovtonyuk, Nike J. Kräutler, Ute Suessbier, Alvaro Gomariz, Gianluca Spaltro, Patrick M. Helbling, Hui Chyn Wong, Takashi Nagasawa, Markus G. Manz, Annette Oxenius, and César Nombela-Arrieta

DOI: 10.1084/jem.20192070
Download Original Video
powered by Glencoe Software