Video 9.

Endogenously desialylated platelets from ST3Gal-IV^Δ/Δ mice bind to Kupffer cells. Time-lapse SD-IVM video of the liver of ST3Gal-IV^Δ/Δ mice. Kupffer cells (blue) were stained using an anti-F4/80 antibody. Endogenous platelets (red) were labeled using an anti-CD49b antibody. Hepatocytes are shown in dark green (autofluorescence). Frame rate is 20 fps.

Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets

Carsten Deppermann, Rachel M. Kratofil, Moritz Peiseler, Bruna A. David, Joel Zindel, Fernanda Vargas E Silva Castanheira, Fardau van der Wal, Agostina Carestia, Craig N. Jenne, Jamey D. Marth, and Paul Kubes

DOI: 10.1084/jem.20190723