Video 8.

Platelets do not accumulate on splenic red pulp macrophages after sialidase injection. Time-lapse SD-IVM video of the spleen of control mice after i.v. injection of 50 mU sialidase. Red pulp macrophages (purple), endothelial cells (red), and platelets (green) were labeled using anti-F4/80, anti-CD31, and anti-CD49b antibodies, respectively. Frame rate is 20 fps.

Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets

Carsten Deppermann, Rachel M. Kratofil, Moritz Peiseler, Bruna A. David, Joel Zindel, Fernanda Vargas E Silva Castanheira, Fardau van der Wal, Agostina Carestia, Craig N. Jenne, Jamey D. Marth, and Paul Kubes

DOI: 10.1084/jem.20190723