Video 10.

Kupffer cells phagocytose desialylated platelets. SD-IVM of the mouse liver after i.v. injection of ex vivo desialylated platelets (CellTracker Red). Kupffer cells (blue) were stained using an anti-F4/80 antibody. Hepatocytes are shown in dark green (autofluorescence). Frame rate is 30 fps.

Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets

Carsten Deppermann, Rachel M. Kratofil, Moritz Peiseler, Bruna A. David, Joel Zindel, Fernanda Vargas E Silva Castanheira, Fardau van der Wal, Agostina Carestia, Craig N. Jenne, Jamey D. Marth, and Paul Kubes

DOI: 10.1084/jem.20190723