MRI of CSF contrast agent spread and outflow in the spine. Maximum-intensity projections video (representative of n = 5 mice) showing spread of tracer after low-rate intraventricular infusion (0.1 Μl per min) of a Gadospin D solution at 25 mM gadolinium. Enhancement of signal in the sacral LN is detectable as early as 30 min and in the iliac LN as early as 42 min following the beginning of contrast agent infusion. Images were acquired at 1 frame per 6.05 min.
