Near-infrared imaging of the dynamics of CSF spread of P40D680 to the sacral region of the spine. Noninvasive imaging of sacral spine at 24× magnification starting at 5 min after intraventricular infusion of 2.5 Μl of 200 ΜM P40D680. Enhancement of thoracic spine is apparent at t = ~16 min (corresponding to ~21 min after the completion of the infusion). Quantification is shown in Fig. 1 C. Images were acquired at 1 frame per 15 s until 60 min after the infusion.
