Video 1.

An episode of a spontaneous behavioral seizure was observed in 16-wk-old Cdh5-Cre;Cdk5^f/f mice. The mouse displays spontaneous seizures with salivation, masticatory jaw movements, and falling, which correspond with the EEG spiking (high frequency and high amplitude) Frame rate, 25.00 frames per second.

Endothelial Cdk5 deficit leads to the development of spontaneous epilepsy through CXCL1/CXCR2-mediated reactive astrogliosis

Xiu-xiu Liu, Lin Yang, Ling-xiao Shao, Yang He, Gang Wu, Yu-huan Bao, Nan-nan Lu, Dong-mei Gong, Ya-ping Lu, Tian-tian Cui, Ning-he Sun, Dan-yang Chen, Wei-xing Shi, Kohji Fukunaga, Hong-shan Chen, Zhong Chen, Feng Han, and Ying-mei Lu

DOI: 10.1084/jem.20180992