Video 4.

Macrophages phagocytose the entire pyroptotic cell corpse and trapped bacteria (related to Fig. 4 ). 106 WT BMMs were labeled with Dextran Alexa555 and infected with SPI1-induced GFP –S. Typhimurium MOI 25 30 min, washed and treated with 15 µg/ml gentamicin for 30 min, and imaged in the absence of antibiotics by live cell confocal microscopy for 2 h.


Pyroptosis triggers pore-induced intracellular traps (PITs) that capture bacteria and lead to their clearance by efferocytosis

Ine Jorgensen, Yue Zhang, Bryan A. Krantz, and Edward A. Miao

DOI: 10.1084/jem.20151613
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