DC movement in RvE1- plus BLT1 antagonist–treated CD11c-YFP mice during skin inflammation. A representative video showing DC movement in the hapten-induced inflammatory skin of RvE1- plus BLT1 antagonist–treated CD11c-YFP mice by two-photon microscopy. The bright green signals indicate CD11c-YFP–positive cells (DCs), and blue signals indicate collagen fibers in the skin. The ear skin of mice was applied with 0.5% DNFB, and the mice were treated with RvE1 plus a BLT1 antagonist 3 h after the hapten application. Observation was started at 1 h after the treatment. DC motility decreased during the observation (time lapse over 120 min; 120 frames, 30 frames/s). Bar, 200 µm. Data are representative of three independent experiments with reproducible results.
