Video 4.

Intravital two-photon microscopy of T cells within skin during acute HSV infection. Shown are several examples of Dock8-deficient (cpm) T cells with elongated processes (white arrows) that break off (circle) as the cell migrates. The last clip shows Dock8-replete WT (gBT-I) control T cells adoptively transferred along with the Dock8-deficient T cells for comparison.

DOCK8 regulates lymphocyte shape integrity for skin antiviral immunity

Qian Zhang, Christopher G. Dove, Jyh Liang Hor, Heardley M. Murdock, Dara M. Strauss-Albee, Jordan A. Garcia, Judith N. Mandl, Rachael A. Grodick, Huie Jing, Devon B. Chandler-Brown, Timothy E. Lenardo, Greg Crawford, Helen F. Matthews, Alexandra F. Freeman, Richard J. Cornall, Ronald N. Germain, Scott N. Mueller, and Helen C. Su

DOI: 10.1084/jem.20141307