Video 6.

2PM image sequence showing WT (blue) and TP^−/− (red) OT-II CD4⁺ T cells interacting with DCs (green) pulsed with 10 µM tOVA. Interactions are labeled as in video 3. Time is shown in minutes and seconds. Bar, 10 µm.

Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell–dendritic cell interactions

Federica Moalli, Jovana Cupovic, Flavian Thelen, Pascal Halbherr, Yoshinori Fukui, Shuh Narumiya, Burkhard Ludewig, and Jens V. Stein

DOI: 10.1084/jem.20140137