Video 2.

2PM image sequence showing WT (blue) and TP^−/− (red) OT-II CD4⁺ T cells and DCs (green) pulsed with 10 µM OVA. Selected WT and TP^−/− OT-II CD4⁺ T cells tracks are shown in blue and red, respectively. Time is shown in minutes and seconds. Bar, 30 µm.

Thromboxane A2 acts as tonic immunoregulator by preferential disruption of low-avidity CD4+ T cell–dendritic cell interactions

Federica Moalli, Jovana Cupovic, Flavian Thelen, Pascal Halbherr, Yoshinori Fukui, Shuh Narumiya, Burkhard Ludewig, and Jens V. Stein

DOI: 10.1084/jem.20140137