Video 1.

Vesicular LAT fusion at the synapse originates and sustains the elongated LAT clusters. 3D live cell videomicroscopy of LAT–GFP-expressing Jurkat cells layed on a anti-CD3–coated coverslip. 2.5 µm optical slice is observed.


Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse

Helena Soares, Ricardo Henriques, Martin Sachse, Leandro Ventimiglia, Miguel A. Alonso, Christophe Zimmer, Maria-Isabel Thoulouze, and Andrés Alcover

DOI: 10.1084/jem.20130150
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