Video 4.

The aspiration of mucus secreted into apical buffer containing 115 mM HCO₃⁻ on CF (CftrΔ508) mouse ileal tissue mounted in the horizontal chamber. The mucus was visualized with charcoal. The first and last images of this video are shown in Fig. 4 C.

Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype

Jenny K. Gustafsson, Anna Ermund, Daniel Ambort, Malin E.V. Johansson, Harriet E. Nilsson, Kaisa Thorell, Hans Hebert, Henrik Sjövall, and Gunnar C. Hansson

DOI: 10.1084/jem.20120562