Video 4.

Proplatelet formation by Bcl-x^Pf4Δ/Pf4Δ megakaryocytes. PS exposure visualized by Annexin V-Alexa Fluor 488 in green.

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

Emma C. Josefsson, Chloé James, Katya J. Henley, Marlyse A. Debrincat, Kelly L. Rogers, Mark R. Dowling, Michael J. White, Elizabeth A. Kruse, Rachael M. Lane, Sarah Ellis, Paquita Nurden, Kylie D. Mason, Lorraine A. O’Reilly, Andrew W. Roberts, Donald Metcalf, David C.S. Huang, and Benjamin T. Kile

DOI: 10.1084/jem.20110750