Video 2.

Interactive three-dimensional reconstruction of LIMP-2 bound to and colocalized with cadherin at the cardiac myocyte intercalated disc in a human heart. This colocalization was seen in healthy as well as in failing human hearts.

Lysosomal integral membrane protein 2 is a novel component of the cardiac intercalated disc and vital for load-induced cardiac myocyte hypertrophy

Blanche Schroen , Joost J. Leenders , Arie van Erk , Anne T. Bertrand , Mirjam van Loon , Rick E. van Leeuwen , Nard Kubben , Rudy F. Duisters , Mark W. Schellings , Ben J. Janssen , Jacques J. Debets , Michael Schwake , Morten A. Høydal , Stephane Heymans , Paul Saftig , and Yigal M. Pinto

DOI: 10.1084/jem.20070145