Video 1.

This movie shows a 50-ns MD simulation of DJ-1 in complex with cPGA. Orange and green represent cPGA and the cPGA-interacting protomer of the DJ-1 dimer, respectively. Cyan indicates the other protomer of the DJ-1 dimer, which provides residue R28 to form the cPGA-binding pocket. The 50-ns simulation is played over 8 s. Fig. 2, B and C; and Fig. 4 A contain related video stills or images.

The reaction mechanism for glycolysis side product degradation by Parkinson’s disease–linked DJ-1

Aiko Watanabe, Shizuka Ogiwara, Mirei Saito, Masaki Mishima, Masahiro Yamashina, Ryuichiro Ishitani, Yutaka Ito, Keiji Tanaka, Fumika Koyano, Koji Yamano, Hidetaka Kosako, Yoshitaka Moriwaki, and Noriyuki Matsuda

DOI: 10.1083/jcb.202411078