Video 6.

TANGO2 structure interacting with one palmitate molecule. The LIL (green) and NRDE (orange) domain analysis in the TANGO2 isoform 1 surface and its modeling interaction with one palmitate molecule predicted by AlphaFold 3.0 and visualized using UCSF ChimeraX.

TANGO2 is an acyl-CoA binding protein

Agustin Leonardo Lujan, Ombretta Foresti, Jose Wojnacki, Gonzalo Bigliani, Nathalie Brouwers, Maria Jesus Pena, Stefania Androulaki, Tomomi Hashidate-Yoshida, Maria Kalyukina, Sergey S. Novoselov, Hideo Shindou, and Vivek Malhotra

DOI: 10.1083/jcb.202410001