Video 4.

Cargo–MT interaction. HeLa cell expressing mCherry-tubulin (green), after uptake of A647-tagged 10 kD dextran (magenta) imaged using spinning disk microscopy. The white arrowheads point to dextran vesicles that remained close to the MTs even when stationary. Imaged at 1 fps, movie playback 3 fps. Scale bar: 5 µm. Movie related to Fig. 4 a.


Single-molecule imaging of stochastic interactions that drive dynein activation and cargo movement in cells

Nireekshit Addanki Tirumala, Gregory Michael Ian Redpath, Sarah Viktoria Skerhut, Pritha Dolai, Natasha Kapoor-Kaushik, Nicholas Ariotti, K. Vijay Kumar, and Vaishnavi Ananthanarayanan

DOI: 10.1083/jcb.202210026
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