Video 1.

Depolarization-induced influx of Zn2+ arrests axonal transport of lysosomes. LAMP1-mCherry labeled lysosomes moving along axons of primary rat hippocampal neurons during baseline, depolarization induced Zn2+ influx (High K + Zn2+), and washout followed by TPEN treatment. Related to Fig. 1.


Zn2+ decoration of microtubules arrests axonal transport and displaces tau, doublecortin, and MAP2C

Taylor F. Minckley, Lyndsie A. Salvagio, Dylan H. Fudge, Kristen Verhey, Steven M. Markus, and Yan Qin

DOI: 10.1083/jcb.202208121
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