Video 3.

3D reconstruction of a microglia that is associated with aberrant myelin ultrastructure in mouse optic nerve. SBF-SEM of a P14 wild-type mouse optic nerve shows a microglia contacting several myelinated axons with aberrant myelin ultrastructure. Video shows raw data with super-imposed pseudo-coloring and 3D reconstructions. Pseudo-coloring shows the microglia in gray blue, while the other colors designate individual myelin sheaths. Related to Fig. 2.


Myelination generates aberrant ultrastructure that is resolved by microglia

Minou Djannatian, Swathi Radha, Ulrich Weikert, Shima Safaiyan, Christoph Wrede, Cassandra Deichsel, Georg Kislinger, Agata Rhomberg, Torben Ruhwedel, Douglas S. Campbell, Tjakko van Ham, Bettina Schmid, Jan Hegermann, Wiebke Möbius, Martina Schifferer, and Mikael Simons

DOI: 10.1083/jcb.202204010
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