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No treatment. Associated with Fig. 3 A. Untreated cells: U2OS PML−/− + YFP-PMLV cells, monitored by fluorescence microscopy every 15 min for 6.75 h (6.75 fps). 5 z-planes spaced at 2 µm. DeltaVision Elite restoration microscope with incubation chamber set to 37°C and 5% CO2. Green indicates YFP (filter set Ex510/10 nm, Em537/26 nm). Scale bars are 5 μm.


The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA

Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, and Ronald T. Hay

DOI: 10.1083/jcb.202201027
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