Plasma membrane invagination showing NRG3 endocytosis. HEK293 cells were transfected with GFP-proNRG3 and imaged 16 h later in live-cell mode (60 s; 1 frame per second) using a high-resolution Airyscan/LSM880 microscope. The time-lapse movie shows invaginating plasma membrane (arrowhead) containing strong GFP signal indicative of NRG3-NTF endocytosis.
