Video 2.

Time evolution of the system with 30 mol% of cholesterol in presence of FGF2 (right panel) and its lateral partial mass density evolution of PI(4,5)P₂ head groups. The video is based on fully atomistic molecular dynamics simulations.

Cholesterol promotes clustering of PI(4,5)P2 driving unconventional secretion of FGF2

Fabio Lolicato, Roberto Saleppico, Alessandra Griffo, Annalena Meyer, Federica Scollo, Bianca Pokrandt, Hans-Michael Müller, Helge Ewers, Hendrik Hähl, Jean-Baptiste Fleury, Ralf Seemann, Martin Hof, Britta Brügger, Karin Jacobs, Ilpo Vattulainen, and Walter Nickel

DOI: 10.1083/jcb.202106123