Video 1.

Time evolution of the lateral partial mass density analysis of PI(4,5)P₂ head groups for membrane systems containing either 0 (left panel) or 30 mol% of cholesterol (right) in the absence of FGF2. The video is based on fully atomistic molecular dynamics simulations.

Cholesterol promotes clustering of PI(4,5)P2 driving unconventional secretion of FGF2

Fabio Lolicato, Roberto Saleppico, Alessandra Griffo, Annalena Meyer, Federica Scollo, Bianca Pokrandt, Hans-Michael Müller, Helge Ewers, Hendrik Hähl, Jean-Baptiste Fleury, Ralf Seemann, Martin Hof, Britta Brügger, Karin Jacobs, Ilpo Vattulainen, and Walter Nickel

DOI: 10.1083/jcb.202106123