Video 4.

CYRI-A regulates actin dynamics at macropinocytic structures. (Four clips; related to Fig. 5.) Clip 1 (related to Fig. 5 A): Airyscan video of a COS-7 cell expressing GFP (cyan) and LifeAct-RFP (magenta). Clip 2 (related to Fig. 5 A): Airyscan video of a COS-7 cell expressing P16-GFP-CYRI-A (cyan) and LifeAct-RFP (magenta). Arrows indicate the vesicles. Clip 3 (related to Fig. 5 B): Airyscan video of a zoom of a COS-7 cell expressing P16-GFP-CYRI-A (cyan) and LifeAct-RFP (magenta). Clip 4 (related to Fig. 5 C): Airyscan video of a zoom of a HEK293T cell expressing P16-GFP-CYRI-A (cyan) and LifeAct-RFP (magenta). Arrows indicate the vesicle with actin around. Acquisition at 9 s/frame and playback at 10 fps.


CYRI-A limits invasive migration through macropinosome formation and integrin uptake regulation

Anh Hoang Le, Tamas Yelland, Nikki R. Paul, Loic Fort, Savvas Nikolaou, Shehab Ismail, and Laura M. Machesky

DOI: 10.1083/jcb.202012114
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