Video 4.

Coculture of C3(1)-Tag organoid with hNK cells limits invasion. DIC time-lapse video of a C3(1)-Tag organoid in coculture with hNK cells, within a collagen I gel. The hNK cells initially suppress invasion completely, but at later time points, the organoid begins to invade. Video frame rate is 10 frames per second.

Cancer cells educate natural killer cells to a metastasis-promoting cell state

Isaac S. Chan, Hildur Knútsdóttir, Gayathri Ramakrishnan, Veena Padmanaban, Manisha Warrier, Juan Carlos Ramirez, Matthew Dunworth, Hao Zhang, Elizabeth M. Jaffee, Joel S. Bader, and Andrew Josef Ewald

DOI: 10.1083/jcb.202001134
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