Nuclear speckles in MFAP1-depleted cells relocate to nucleolar periphery after DRB treatment. Time-lapse video of MFAP1-depleted U2OS cell expressing GFP-ZNF207 nuclear speckle marker and treated with DRB. Arrow points to a nuclear speckle that moves to and then merges with nucleolar periphery. After contacting the nucleolar periphery, the speckle flattens in shape and its contents appear to then spread out and partially encircle the nucleolar periphery. Time (top left corner) in hours:minutes format.
