Video 5.

Point mutation of both SxIP motifs mediating NAV1 binding to EB1 impairs its MT plus-end tracking ability in F-actin–rich regions of GCs. Related to Fig. 3 K. Time-lapse microscopy of neurons expressing EB3-mCherry, Lifeact-Tq, and either GFP-NAV1-WT (top) or GFP-NAV1-EBmut (bottom). Time interval: 1 second.


The +TIP Navigator-1 is an actin–microtubule crosslinker that regulates axonal growth cone motility

Carlos Sánchez-Huertas, Marion Bonhomme, Amandine Falco, Christine Fagotto-Kaufmann, Jeffrey van Haren, Freddy Jeanneteau, Niels Galjart, Anne Debant, and Jérôme Boudeau

DOI: 10.1083/jcb.201905199
Download Original Video
powered by Glencoe Software