Video 3.

NAV1 depletion impairs axon turning toward a netrin-1 gradient. Related to Fig. 2. Phase-contrast time-lapse microscopy of control (shRNA-luc) and NAV1-depleted (shRNA-NAV1#1) neurons exposed to netrin-1 in a Dunn chamber. The higher concentration of netrin-1 is at the top of the images. Time interval: 4 minutes.


The +TIP Navigator-1 is an actin–microtubule crosslinker that regulates axonal growth cone motility

Carlos Sánchez-Huertas, Marion Bonhomme, Amandine Falco, Christine Fagotto-Kaufmann, Jeffrey van Haren, Freddy Jeanneteau, Niels Galjart, Anne Debant, and Jérôme Boudeau

DOI: 10.1083/jcb.201905199
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