Video 2.

Confocal Z-series of the A549 Rab10 knockout cell shown in Fig. 9 B expressing GFP-R1441G LRRK2, Myc-GBP, and PM-Rab10 to illustrate the localization of plasma membrane–anchored Rab10 distributiondetected in the 647-nm channel. The video was created at 3 frames per second.


Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases

Rachel C. Gomez, Paulina Wawro, Pawel Lis, Dario R. Alessi, and Suzanne R. Pfeffer

DOI: 10.1083/jcb.201902184
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