Video 4.

Wild-type neuron undergoing Slit-induced filopodium elongation and neurite retraction. After bath application of Slit, this wild-type growth cone can be seen to undergo a dramatic morphological change: filopodia dramatically lengthen, whereas the lamellipodial area collapses. After growth cone collapse, the entire axon retracts.


A requirement for filopodia extension toward Slit during Robo-mediated axon repulsion

Russell E. McConnell, J. Edward van Veen, Marina Vidaki, Adam V. Kwiatkowski, Aaron S. Meyer, and Frank B. Gertler

DOI: 10.1083/jcb.201509062
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