HDS-modeled graph representations of five global phenotypical classes. HDS-modeled graph representations time-lapse video of the five phenotypical classes extracted from Fig. 6 is shown in inverted black-and-white contrast. From top left to bottom right: control siRNA, short neurite phenotype, spread soma/multiple and/or branched short neurites phenotype, long and unbranched neurite phenotype, and long and branched neurite phenotype. Bar, 100 µm.