Video 5.

P-cadherin expression increases traction forces at the multicellular leading row. Evolution of Tx of migrating C2C12 LZRS (left) and C2C12 Pcad cells (right) during a 10-h time course; 1 frame/30 min. Maximum Tx of cells moving to the left appear in yellow; maximum Tx of cells moving to the right appear in blue.

P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces

Cédric Plutoni, Elsa Bazellieres, Maïlys Le Borgne-Rochet, Franck Comunale, Agusti Brugues, Martial Séveno, Damien Planchon, Sylvie Thuault, Nathalie Morin, Stéphane Bodin, Xavier Trepat, and Cécile Gauthier-Rouvière

DOI: 10.1083/jcb.201505105