Video 3.

P-cadherin expression modifies FA organization and dynamics. Top, inverted confocal images of paxillin-GFP in migrating C2C12 LZRS (left) and C2C12 Pcad cells (right) located at the first multicellular row; 1 frame/5 s for 15 min. Arrows indicate the migration direction. Lines in the first frame indicate nontransfected surrounding cells. Bottom, ratio images generated from the time-lapse shown at top to illustrate FA dynamics, with magenta showing the extension and yellow the loss of FAs. Green represents the FA area maintained during the analyzed period.


P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces

Cédric Plutoni, Elsa Bazellieres, Maïlys Le Borgne-Rochet, Franck Comunale, Agusti Brugues, Martial Séveno, Damien Planchon, Sylvie Thuault, Nathalie Morin, Stéphane Bodin, Xavier Trepat, and Cécile Gauthier-Rouvière

DOI: 10.1083/jcb.201505105
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