Video 10.

Cdc42 or β-PIX inhibition perturbs P-cadherin–dependent traction-force generation of migrating cells. Evolution of Tx of migrating C2C12 Pcad Cdc42 shRNA (left) and C2C12 Pcad β-PIX shRNA (right) cells during a 10-h time course; 1 frame/30 min.

P-cadherin promotes collective cell migration via a Cdc42-mediated increase in mechanical forces

Cédric Plutoni, Elsa Bazellieres, Maïlys Le Borgne-Rochet, Franck Comunale, Agusti Brugues, Martial Séveno, Damien Planchon, Sylvie Thuault, Nathalie Morin, Stéphane Bodin, Xavier Trepat, and Cécile Gauthier-Rouvière

DOI: 10.1083/jcb.201505105