Video 5.

Mena forms a ring around the Tks5 core. MDA-MB-231 cells were transiently cotransfected with mCherry-Tks5 and GFP-Mena, cultured on unconjugated matrix for 24 h, and subjected to time-lapse video microscopy. Images were acquired every 15 s for 5 min and are displayed at 3/10 of a second per frame. GFP-Mena is depicted on the left and mCherry-Tks5 on the right. Bars, 10 µm.


5′-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion

Charles V. Rajadurai, Serhiy Havrylov, Paula P. Coelho, Colin D.H. Ratcliffe, Kossay Zaoui, Bruce H. Huang, Anie Monast, Naila Chughtai, Veena Sangwan, Frank B. Gertler, Peter M. Siegel, and Morag Park

DOI: 10.1083/jcb.201501003
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