Video 7.

Receptor dimerization probed by colocomotion analysis. IFNAR1 (labeled with TMR, red signals) and IFNAR2 (labeled with DY647, blue signals) were imaged by TIRFM (Olympus IX71) in the absence (left) and presence (right) of IFNα2 (frame rate, 30 Hz; playback, real time). Colocomotion trajectories are indicated in yellow.

Receptor dimerization dynamics as a regulatory valve for plasticity of type I interferon signaling

Stephan Wilmes, Oliver Beutel, Zhi Li, Véronique Francois-Newton, Christian P. Richter, Dennis Janning, Cindy Kroll, Patrizia Hanhart, Katharina Hötte, Changjiang You, Gilles Uzé, Sandra Pellegrini, and Jacob Piehler

DOI: 10.1083/jcb.201412049