Video 2.

Mtm alters PI(3)P compartment dynamics. Time-lapse confocal microscopy video of PI(3)P detected with mCherry2xFYVE in live control (ctrl) and mtm-depleted hemocytes (Cg-GAL4) taken with a point-scanning confocal microscope (FV1000). Note that extension and retraction of apparent tubulation from compartments in control cells (left) were not observed in mtm-depleted cells (right). Frames were taken every 15 s for 5 min.


Drosophila Mtm and class II PI3K coregulate a PI(3)P pool with cortical and endolysosomal functions

Michaella Velichkova, Joe Juan, Pavan Kadandale, Steve Jean, InĂªs Ribeiro, Vignesh Raman, Chris Stefan, and Amy A. Kiger

DOI: 10.1083/jcb.200911020
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