Video 2.

Random motility of FAK^−/− MEFs on fibronectin. Cells were plated onto 1-µg/ml FN–coated glass slides with 10% FBS and maintained at 37°C. Phase-contrast images at 20× were obtained every 5 min and 105 sequential images (8 h and 45 min) are shown at 15 frames per second.

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

Yangmi Lim , Ssang-Taek Lim , Alok Tomar , Margaret Gardel , Joie A. Bernard-Trifilo , Xiao Lei Chen , Sean A. Uryu , Rafaela Canete-Soler , Jinbin Zhai , Hong Lin , William W. Schlaepfer , Perihan Nalbant , Gary Bokoch , Dusko Ilic , Clare Waterman-Storer , and David D. Schlaepfer

DOI: 10.1083/jcb.200708194