Modulation of cellular contractility signaling by matrix elasticity. Time-lapse videos of Myosin IIa (EGFP-NMHCIIa) in resting, untreated U2OS cells 12 h after plating on collagen-coated gel substrates with an elasticity of 10 kPa (left) or 300 kPa (right). Images were collected via spinning disk confocal microscopy using a frame rate of 20/min. Bars, 10 µm.
