Video 9.

Drp1-independent wholesale mitochondrial fission after Parkin recruitment to mitochondria. Live imaging of Tet-ON: ΔOTC-expressing Drp1 KO HeLa cells expressing YFP-Parkin (green), labeled with TMRM (red), treated with DOX for 48 h, and labeled with TMRM (red). Time is indicated. Frame rate, four frames/s.

Mitochondrial fission facilitates the selective mitophagy of protein aggregates

Jonathon L. Burman, Sarah Pickles, Chunxin Wang, Shiori Sekine, Jose Norberto S. Vargas, Zhe Zhang, Alice M. Youle, Catherine L. Nezich, Xufeng Wu, John A. Hammer, and Richard J. Youle

DOI: 10.1083/jcb.201612106